Abstract
The method of micronuclei account allowed to demonstrate protective effect of gossypol and its derivatives megacin and batriden of chromosomes of rat male germ cells from mutagenic effect of nitrosomethylurea (NMU) and, conversely, enhancement of clastogenic effect of another alkylating agent, fotrin. Strong antimutagenic effect of gossypol from NMU was also observed in external granular layer of young rat cerebellum. Possible mechanisms of antimutagenic action of this unique polyphenol of cotton plant are discussed.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Alkylating Agents / toxicity
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Animals
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Animals, Newborn
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Aziridines / toxicity
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Cerebellum / drug effects
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Cerebellum / ultrastructure
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Chromosome Aberrations*
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Drug Interactions
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Gossypol / analogs & derivatives*
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Gossypol / toxicity*
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Male
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Methylnitrosourea / toxicity
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Micronucleus Tests
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Rats
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Rats, Wistar
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Spermatogenesis / drug effects
Substances
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Alkylating Agents
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Aziridines
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fotrin
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batridene
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Methylnitrosourea
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gossypol beta-aminoethyl sodium sulfate
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Gossypol