Lanthanide ions for the first non-enzymatic formation of adenosine 3',5'-cyclic monophosphate from adenosine triphosphate under physiological conditions

H Yajima; J Sumaoka; S Miyama; M Komiyama

doi:10.1093/oxfordjournals.jbchem.a124453

Lanthanide ions for the first non-enzymatic formation of adenosine 3',5'-cyclic monophosphate from adenosine triphosphate under physiological conditions

J Biochem. 1994 Jun;115(6):1038-9. doi: 10.1093/oxfordjournals.jbchem.a124453.

Authors

H Yajima¹, J Sumaoka, S Miyama, M Komiyama

Affiliation

¹ Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo.

PMID: 7982878
DOI: 10.1093/oxfordjournals.jbchem.a124453

Abstract

Adenosine 3',5'-cyclic monophosphate (cAMP) is formed from adenosine triphosphate at pH 8 and 50 degrees C by use of lanthanide ions. Pr3+ and La3+ are the most active. The cAMP formation is more efficient at higher pH, where the mixture is made homogeneous by the addition of beta-cyclodextrin. The potential functioning of lanthanide ions as the catalytic center of an artificial adenylate cyclase is indicated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate / chemistry*
Cyclic AMP / chemical synthesis*
Hydrogen-Ion Concentration
Metals, Rare Earth / chemistry*

Substances

Metals, Rare Earth
Adenosine Triphosphate
Cyclic AMP