Synthesis and cytotoxic activity of new isothiazolo[5,4-d]pyrimidine derivatives

U Lipnicka; A Regiec; Z Machon

Synthesis and cytotoxic activity of new isothiazolo[5,4-d]pyrimidine derivatives

Pharmazie. 1994 Sep;49(9):642-6.

Authors

U Lipnicka¹, A Regiec, Z Machon

Affiliation

¹ Organic Chemistry Department, Faculty of Pharmacy, Medical Academy, Wroclaw, Poland.

PMID: 7972309

Abstract

The synthesis of new 5-amino-3-methylisothiazolo[5,4-d]pyrimidines series is reported. The cytotoxic activity of these compounds has been determined on the two tumor cell lines (P-388 and KB). Two representative compounds 7 and 8 displayed a significant cytotoxic action. The results point a possible involvement of structural features in the inhibition effect against tumors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Cell Survival / drug effects
Drug Screening Assays, Antitumor
Humans
KB Cells
Leukemia P388 / drug therapy
Mice
Pyrimidines / chemical synthesis*
Pyrimidines / pharmacology

Substances

Antineoplastic Agents
Pyrimidines