Abstract
A diversity of high-affinity oligosaccharide ligands are identified for NKR-P1, a membrane protein on natural killer (NK) cells which contains an extracellular Ca(2+)-dependent lectin domain. Interactions of such oligosaccharides on the target cell surface with NKR-P1 on the killer cell surface are crucial both for target cell recognition and for delivery of stimulatory or inhibitory signals linked to the NK cytolytic machinery. NK-resistant tumour cells are rendered susceptible by preincubation with liposomes expressing NKR-P1 ligands, suggesting that purging of tumour or virally infected cells in vivo may be a therapeutic possibility.
Publication types
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Research Support, Non-U.S. Gov't
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Retracted Publication
MeSH terms
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Animals
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Antigens, Surface / physiology*
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Carbohydrate Sequence
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Cytotoxicity, Immunologic / physiology*
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Glycolipids / immunology
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Killer Cells, Natural / physiology*
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Lectins / physiology*
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Lectins, C-Type*
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Lymphocyte Activation / physiology
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Male
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Molecular Sequence Data
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NK Cell Lectin-Like Receptor Subfamily B
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Oligosaccharides / immunology*
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Rats
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Rats, Inbred F344
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Receptors, Immunologic / physiology*
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Tumor Cells, Cultured
Substances
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Antigens, Surface
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Glycolipids
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Lectins
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Lectins, C-Type
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NK Cell Lectin-Like Receptor Subfamily B
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Oligosaccharides
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Receptors, Immunologic