Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats

Abstract

To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABAB receptor activation, we tested the effects of intranigral CGP 35,348 (a GABAB receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats. In pups, nigral infusions of CGP 35,348 decreased the thresholds for clonic and tonic seizures and attenuated the anticonvulsant effects of GVG. In adults, nigral infusions of CGP 35,348 did not alter seizure thresholds. The data suggest that, in rat pups, nigral GABAB receptors regulate, in part, flurothyl-induced seizures.