Potential-dependent Ca2+ currents in isolated heart cells of hibernators

Biochem Mol Biol Int. 1994 May;33(2):365-75.

Abstract

Using the perforated patch-clamp technique, it has been shown that the potential-dependent Ca2+ current in cardiac myocytes of hibernators is not completely inhibited during hibernation. The residual Ca2+ current is classed as L-type Ca2+ current which is regulated by agonists and antagonists of Ca2+ channels. The effect of nifedipine, D600, isoproterenol and forskolin has been examined. It was found that isoproterenol affects the affinity of Ca2+ channels for the D600 blocker.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / drug effects
  • Cells, Cultured
  • Colforsin / pharmacology
  • Electric Conductivity
  • Electrophysiology
  • Gallopamil / pharmacology
  • Heart / drug effects
  • Hibernation / physiology*
  • Isoproterenol / pharmacology
  • Membrane Potentials
  • Myocardium / cytology
  • Myocardium / metabolism*
  • Nifedipine / pharmacology
  • Patch-Clamp Techniques
  • Sciuridae

Substances

  • Calcium Channels
  • Colforsin
  • Gallopamil
  • Nifedipine
  • Isoproterenol
  • Calcium