Abstract
Using the perforated patch-clamp technique, it has been shown that the potential-dependent Ca2+ current in cardiac myocytes of hibernators is not completely inhibited during hibernation. The residual Ca2+ current is classed as L-type Ca2+ current which is regulated by agonists and antagonists of Ca2+ channels. The effect of nifedipine, D600, isoproterenol and forskolin has been examined. It was found that isoproterenol affects the affinity of Ca2+ channels for the D600 blocker.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Channels / drug effects
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Cells, Cultured
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Colforsin / pharmacology
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Electric Conductivity
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Electrophysiology
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Gallopamil / pharmacology
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Heart / drug effects
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Hibernation / physiology*
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Isoproterenol / pharmacology
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Membrane Potentials
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Myocardium / cytology
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Myocardium / metabolism*
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Nifedipine / pharmacology
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Patch-Clamp Techniques
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Sciuridae
Substances
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Calcium Channels
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Colforsin
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Gallopamil
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Nifedipine
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Isoproterenol
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Calcium