Pulsatile growth pattern during catch-up growth in childhood coeliac disease

Acta Paediatr. 1994 Jul;83(7):724-9. doi: 10.1111/j.1651-2227.1994.tb13127.x.

Abstract

Catch-up growth in coeliac disease was thought to be a continuous process and hence linear models have been proposed to interpret the pattern of catch-up growth. Observed longitudinal data do not fit a linear model adequately. The aim of this study is to clarify the pattern of short-term catch-up growth in coeliac patients. Twenty-one coeliac children (aged 6-24 months) entered the study and were monitored at short-time intervals. All showed a "pulsatile" pattern of growth velocity for height, weight, leg length, subscapular and triceps skinfolds. Peaks alternated with troughs at a mean time of 62 days for the whole set of measurements. The periodicity was remarkably stable. The size of the peaks decreased with time on a gluten-free diet. Catch-up growth is a discontinuous process made up of a sequence of bursts of growth followed by a resting phase. This provides strong evidence for the possibility that short-term growth may be pulsatile.

MeSH terms

  • Body Height
  • Body Weight
  • Celiac Disease / complications*
  • Celiac Disease / diet therapy
  • Female
  • Growth Disorders / diagnosis
  • Growth Disorders / etiology
  • Growth Disorders / physiopathology*
  • Humans
  • Infant
  • Linear Models
  • Longitudinal Studies
  • Male
  • Periodicity*
  • Skinfold Thickness
  • Time Factors