3 alpha-hydroxysteroid dehydrogenase inhibitory activity of some N(3)-(1-R-4-carboxypyrazol-5-yl)-1,2,3-benzotriazin-4(3H)-one and quinazolin-4(3H)-one acids

S Plescia; D Raffa; G Daidone; D Schillaci; B Maggio

3 alpha-hydroxysteroid dehydrogenase inhibitory activity of some N(3)-(1-R-4-carboxypyrazol-5-yl)-1,2,3-benzotriazin-4(3H)-one and quinazolin-4(3H)-one acids

Farmaco. 1994 Jul-Aug;49(7-8):505-7.

Authors

S Plescia¹, D Raffa, G Daidone, D Schillaci, B Maggio

Affiliation

¹ Dipartimento di Chimica e Tecnologie Farmaceutiche dell'Università degli Studi, Palermo, Italy.

PMID: 7945717

Abstract

Some carboxylic acids of N(3)-pyrazole substituted 1,2,3-benzotriazin-4-(3H)-ones and- quinazolin-4-(3H)-ones were prepared and tested for the inhibitory property of 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol. The results indicated that the degree of inhibition can be used to predict the antiinflammatory potency of the compounds described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3-Hydroxysteroid Dehydrogenases / antagonists & inhibitors*
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Rats
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents, Non-Steroidal
3-Hydroxysteroid Dehydrogenases
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)