Synthesis of substituted [1]benzothieno[2,3-b]pyrazines and their ability to antagonize KCl induced contractions

F Guerrera; L Salerno; M C Sarvà; M A Siracusa; A Rescifina; R Scalia; A Bianchi

Synthesis of substituted [1]benzothieno[2,3-b]pyrazines and their ability to antagonize KCl induced contractions

Farmaco. 1994 Jul-Aug;49(7-8):467-73.

Authors

F Guerrera¹, L Salerno, M C Sarvà, M A Siracusa, A Rescifina, R Scalia, A Bianchi

Affiliation

¹ Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italy.

PMID: 7945711

Abstract

A series of substituted [1]benzothieno [2,3-b]pyrazines, structurally related to caroverine, was synthesized. Some of these compounds showed an appreciable inhibition towards KCl induced contractions on isolated rat aortic rings, and a lower potency towards negative inotropic activity tested on isolated guinea pig atrium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aorta / drug effects
Aorta / physiology
Calcium Channel Blockers / chemical synthesis*
Calcium Channel Blockers / pharmacology
In Vitro Techniques
Potassium Chloride / pharmacology
Pyrazines / chemical synthesis*
Pyrazines / pharmacology
Quinoxalines / chemical synthesis*
Quinoxalines / pharmacology
Rats
Rats, Wistar
Structure-Activity Relationship
Vasoconstriction / drug effects*

Substances

Calcium Channel Blockers
Pyrazines
Quinoxalines
Potassium Chloride
caroverine