The hepatic recurrent rate after hepatic resection of colorectal liver metastases was 60-70%. Prevention of residual hepatic recurrence will result in a markedly better prognostic outcome. Thus, 51 patients with liver metastases of colorectal carcinoma were administered 5-FU from gastroduodenal artery after hepatectomy. The results were as follows: the cumulative 5-year survival rate; hepatic arterial infusion (+): 43.4%; (-): 18.5% (p < 0.05); the residual hepatic recurrent rate, hepatic arterial infusion (+): 33.3%; (-): 58.6% (p < 0.05); The total dose of 5-FU > or = 15 g administration group got less residual hepatic recurrent rate; and proved rather effective for prevention of residual hepatic recurrence. But the 5-year survival rate in extra-hepatic recurrence (+) was 14.1% and that of (-) was 70.9% (p < 0.001). In future, it will be necessary to prevent extra-hepatic recurrence after hepatectomy.