Medical management of patients with Zollinger-Ellison syndrome has considerably evolved since initial reports in 1955 and especially over the last decade. Control of gastric hypersecretion by effective antisecretory drugs, accurate localization and staging of the tumoral process by modern medical imaging techniques as well as progress in surgical skill undoubtedly account for higher rates of gastrinoma definitive or long-lasting cure. Elective surgery for gastrinoma removal may indeed be safely undertaken in selected patients. Current diagnostic and treatment strategies have been discussed here, by reference to the literature and a large personal series of patients followed at Bichat-Claude-Bernard Hospital for 30 years. The specific case of gastrinoma associated with multiple endocrine neoplasia type I is also discussed.