Abstract
The integrase encoded by the integron of the transposon Tn21 can mediate the site-specific fusion of two plasmids if there is a recombination hot spot (59 bp element) in one of them and the sequence GWTMW in the other. The use of this latter, loosely defined site explains how antibiotic-resistance genes could first become associated with integrons.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Binding Sites / genetics
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DNA Nucleotidyltransferases / genetics*
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DNA Nucleotidyltransferases / metabolism
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DNA Transposable Elements*
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DNA, Bacterial / genetics
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Escherichia coli / enzymology*
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Escherichia coli / genetics*
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Integrases
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Molecular Sequence Data
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Plasmids / genetics
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Recombination, Genetic
Substances
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DNA Transposable Elements
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DNA, Bacterial
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DNA Nucleotidyltransferases
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Integrases