Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10

J Virol. 1994 Nov;68(11):7575-81. doi: 10.1128/JVI.68.11.7575-7581.1994.

Abstract

Analysis of the respiratory tract before and after primary influenza virus infection revealed a virus-induced preferential accumulation of a CD8+ T-cell population that coexpresses mRNA for interleukin-5 (IL-5) and IL-10 with virus dose-dependent high levels of gamma interferon. However, cytokine production in lung tissues was not restricted to the T-cell population, since CD3- cells were found to express mRNA for various cytokines, including IL-4 and particularly IL-6 and granulocyte-macrophage colony-stimulating factor. These data provide in vivo evidence for a local respiratory tract immune response to influenza virus infection dominated by cytokine-producing CD8+ T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • CD3 Complex / analysis
  • Cytokines / biosynthesis
  • Cytokines / genetics*
  • Female
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / genetics
  • Interleukin-10 / biosynthesis
  • Interleukin-10 / genetics
  • Interleukin-5 / biosynthesis
  • Interleukin-5 / genetics
  • Lung / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Orthomyxoviridae Infections / immunology*
  • Orthomyxoviridae Infections / metabolism
  • RNA, Messenger / analysis*
  • T-Lymphocytes / immunology*

Substances

  • CD3 Complex
  • Cytokines
  • Interleukin-5
  • RNA, Messenger
  • Interleukin-10
  • Interferon-gamma