Structure-based drug design: progress, results and challenges

C L Verlinde; W G Hol

doi:10.1016/s0969-2126(00)00060-5

Structure-based drug design: progress, results and challenges

Structure. 1994 Jul 15;2(7):577-87. doi: 10.1016/s0969-2126(00)00060-5.

Authors

C L Verlinde¹, W G Hol

Affiliation

¹ Department of Biological Structure, School of Medicine, University of Washington, Seattle 98195.

PMID: 7922037
DOI: 10.1016/s0969-2126(00)00060-5

Abstract

Protein structure-based drug design is rapidly gaining momentum. The new opportunities, developments and results in this field are almost unbelievable compared with the situation less than a decade ago.

Publication types

Review

MeSH terms

Algorithms
Binding Sites
Computer Simulation
Drug Design*
Enzyme Inhibitors
Ligands
Pharmacology / methods*
Pharmacology / trends
Protein Conformation*

Substances

Enzyme Inhibitors
Ligands