IMOL 881, a new trypanocidal compound

Acta Trop. 1993 Sep;54(3-4):261-9. doi: 10.1016/0001-706x(93)90098-v.

Abstract

A new drug molecule (IMOL 881) was synthesized and is showing interesting trypanocidal properties. The test results on animal models indicate activity against several trypanosome species, both in the veterinary and in the human medicine application fields. The species tested so far include: T. evansi, T. equiperdum, T. gambiense and T. rhodesiense. The good activity combined with a relatively low toxicity results in a high therapeutic index (> 100). In addition to its curative properties, the drug also seems to exhibit a prophylactic potential, as evidenced by tests on drug treated mice, subsequently infected with T. evansi.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arsenicals* / chemistry
  • Arsenicals* / pharmacology
  • Arsenicals* / therapeutic use
  • Drug Evaluation, Preclinical
  • Humans
  • Mice
  • Triazines* / chemistry
  • Triazines* / pharmacology
  • Triazines* / therapeutic use
  • Trypanocidal Agents* / chemistry
  • Trypanocidal Agents* / pharmacology
  • Trypanocidal Agents* / therapeutic use
  • Trypanosoma / drug effects
  • Trypanosomiasis, African / drug therapy*
  • Trypanosomiasis, African / parasitology
  • Trypanosomiasis, African / veterinary

Substances

  • Arsenicals
  • Triazines
  • Trypanocidal Agents
  • IMOL 881