Abstract
We report a 37-year-old female HTLV-I carrier with complicating primary biliary cirrhosis (PBC) and mixed connective tissue disease (MCTD). Serum anti-HTLV-I antibody titer was x256. Flower cells (4.5%) were found in the peripheral blood. Southern blot analysis showed no clonal integration in peripheral blood lymphocyte (PBL) DNA. Polymerase chain reaction showed the HTLV-I genome in PBL DNA. As cholestatic liver dysfunction and serum titer of anti-mitochondrial antibody were found, a clinical diagnosis of PBC was made. This patient later developed MCTD. These diseases responded well to prednisone. The pathogenetic relationship of HTLV-I infection with various autoimmune diseases is discussed.
MeSH terms
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Adult
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Antibody Specificity
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Autoantibodies / blood*
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Autoantibodies / immunology
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Autoimmune Diseases / complications*
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Autoimmune Diseases / immunology
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Autoimmune Diseases / microbiology
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Carrier State / immunology*
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DNA, Viral / blood
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Deltaretrovirus Antibodies / blood
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Disease Susceptibility
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Female
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HLA Antigens / analysis
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HTLV-I Infections / complications*
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HTLV-I Infections / immunology
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Human T-lymphotropic virus 1 / isolation & purification
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Human T-lymphotropic virus 1 / pathogenicity*
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Humans
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Liver Cirrhosis, Biliary / complications*
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Liver Cirrhosis, Biliary / drug therapy
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Liver Cirrhosis, Biliary / immunology
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Lymphocytes / microbiology
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Mixed Connective Tissue Disease / complications*
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Mixed Connective Tissue Disease / drug therapy
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Mixed Connective Tissue Disease / immunology
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Polymerase Chain Reaction
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Polyradiculoneuropathy / complications
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Prednisone / therapeutic use
Substances
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Autoantibodies
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DNA, Viral
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Deltaretrovirus Antibodies
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HLA Antigens
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Prednisone