6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells

J Cancer Res Clin Oncol. 1995;121(2):98-102. doi: 10.1007/BF01202220.

Abstract

6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference in p53 and c-myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Ascorbic Acid / analogs & derivatives*
  • Ascorbic Acid / pharmacology
  • DNA / metabolism
  • Humans
  • Neoplasms / pathology*
  • Proto-Oncogene Proteins c-myc / analysis
  • Tumor Cells, Cultured
  • Tumor Suppressor Protein p53 / analysis

Substances

  • 6-amino-6-deoxyascorbic acid
  • Antineoplastic Agents
  • Proto-Oncogene Proteins c-myc
  • Tumor Suppressor Protein p53
  • DNA
  • Ascorbic Acid