Maturation of the GFAP-immunopositive glial network is delayed in the olfactory bulbs of rats subjected to early, low-dose X-irradiation

Glia. 1994 Oct;12(2):144-50. doi: 10.1002/glia.440120208.

Abstract

Young rats were subjected to low-level, repeated doses of x-irradiation from a Co60 source and examined for the presence and arrangement of their GFAP-immunopositive system at the light and electron microscopic levels. In 2-week-old control rats, labelled cells were already distributed homogeneously throughout the bulb, while in the experimental animals, a (newborn- and early postnatal-type) radial arrangement of immunoreactive fibres continued to persist even until the end of the fourth postnatal week. This delay in the maturation of the GFAP-immunopositive glial system may contribute to the hindered development of the bulbar neurones, neuronal connections, and field potentials, as found in earlier studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Dose-Response Relationship, Drug
  • Glial Fibrillary Acidic Protein / analysis
  • Glial Fibrillary Acidic Protein / metabolism*
  • Immunohistochemistry
  • Microscopy, Immunoelectron
  • Nerve Fibers / physiology*
  • Nerve Fibers / radiation effects
  • Nerve Fibers / ultrastructure
  • Neuroglia / physiology*
  • Neuroglia / radiation effects
  • Neuroglia / ultrastructure
  • Olfactory Bulb / cytology
  • Olfactory Bulb / physiology
  • Olfactory Bulb / radiation effects*
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • X-Rays

Substances

  • Glial Fibrillary Acidic Protein