Hepatitis was regarded as a main health problem in Shashi city, Hubei province, according to DSP data at present. The case-control study of hepatitis risk factors were carried out among 115 hepatitis cases and 60 controls that all were negative serologically in Shashi city. The result indicates that economic status, way of having breakfast outside, habits of washing hands before meals and after feces, levels of knowing about route of infection of hepatitis are independently associated with morbidity probability of hepatitis A, the comprehensive preventive measures are presented in the light of these conclusions.