Abstract
The aim of the present study is to investigate the effect of neonatal alterations in 5-HT signalling on the regulation of endocrine stress response in adult rats. The neonatal blockade of 5-HT transmission by 5,7-DHT or ritanserin treatment did not alter the density of glucocorticoid receptor (GR) binding sites in the hippocampus, although a 5,7-DHT-induced lesion was clearly shown to decrease in 5-HT content by greater than 80% in the hippocampus. In addition, the animals pretreated with the blockade of 5-HT transmission during early life did not exhibit a hyperresponsiveness of the adrenocortical response to stress. On the other hand, the neonatal administration of the 5-HT uptake inhibitor, clomipramine, was shown to lower the stress responsiveness of the adrenocortical axis in adulthood.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5,7-Dihydroxytryptamine / administration & dosage
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5,7-Dihydroxytryptamine / pharmacology
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5,7-Dihydroxytryptamine / toxicity*
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Adrenal Cortex / growth & development
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Adrenal Cortex / physiology*
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Animals
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Animals, Newborn
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Brain Chemistry / drug effects
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Clomipramine / administration & dosage
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Clomipramine / pharmacology*
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Dexamethasone / pharmacology
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Feedback
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Hippocampus / drug effects*
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Hippocampus / growth & development
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Hippocampus / metabolism
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Hydrocortisone / metabolism*
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Hypothalamo-Hypophyseal System / physiopathology
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Pituitary-Adrenal System / physiopathology
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Rats
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Rats, Sprague-Dawley
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Receptors, Glucocorticoid / metabolism*
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Restraint, Physical
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Ritanserin / administration & dosage
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Ritanserin / pharmacology*
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Serotonin / physiology*
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Stress, Physiological / physiopathology
Substances
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Receptors, Glucocorticoid
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Ritanserin
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5,7-Dihydroxytryptamine
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Serotonin
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Dexamethasone
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Clomipramine
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Hydrocortisone