Abstract
Patients treated with interferon alfa can develop autoantibodies and autoimmune diseases. We describe two patients who developed myasthenia gravis with abnormal levels of serum anti-acetylcholine receptor antibodies during interferon alfa-2b treatment for malignancies. One of these patients had myopathic findings on EMG and focal deficiency of cytochrome c oxidase on muscle biopsy.
MeSH terms
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Cytochrome-c Oxidase Deficiency
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Electromyography
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Electron Transport Complex IV / analysis
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Humans
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Interferon alpha-2
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Interferon-alpha / adverse effects*
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Interferon-alpha / therapeutic use
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Lymphoma, Non-Hodgkin / drug therapy*
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Male
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Middle Aged
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Muscle Fibers, Skeletal / enzymology
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Muscle Fibers, Skeletal / pathology
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Myasthenia Gravis / chemically induced*
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Myasthenia Gravis / pathology
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Myasthenia Gravis / physiopathology
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Recombinant Proteins
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Succinate Dehydrogenase / analysis
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Urinary Bladder Neoplasms / surgery
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Urinary Bladder Neoplasms / therapy*
Substances
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Interferon alpha-2
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Interferon-alpha
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Recombinant Proteins
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Succinate Dehydrogenase
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Electron Transport Complex IV