Nomadism is a highly specialised mode of life that enables humans to exploit resources that are widely distributed over space and time. The isolation and remoteness of many nomad populations have limited studies on the macroepidemiology of parasitic infection in nomad populations. From the available information, the influence of a number of factors on the prevalence and transmission of parasitic infections in nomads is discussed. Environmental conditions, especially relative humidity and temperature, profoundly influence parasitic diseases. Human behaviour varies with cultural factors and influences exposure to disease. Periodic movements of nomads may either remove them and their animals from contaminated environments or may bring then into contact, often seasonally, with infections. There may be a strong ecological interdependence between diet and infection and disease in nomadic groups. Finally, the influence of drought can be profound in that seasonal or prolonged drought promotes concentration of populations in small areas or their sedenterisation, often with an increase in parasite transmission. Relevant information that needs to be acquired to develop appropriate practical and cost-effective health and veterinary care and control programmes for nomadic populations and their livestock is outlined.