Inhibitory activity of 3-methylenhydroxy-5-methoxy-2,4-dihydroxy tetrahydrofurane isolated from Selaginella lepidophyla on smooth muscle of Wistar rat

S Pérez; R M Pérez; C Pérez; M A Zavala; R Vargas

doi:10.1016/0031-6865(94)90016-7

Inhibitory activity of 3-methylenhydroxy-5-methoxy-2,4-dihydroxy tetrahydrofurane isolated from Selaginella lepidophyla on smooth muscle of Wistar rat

Pharm Acta Helv. 1994 Dec;69(3):149-52. doi: 10.1016/0031-6865(94)90016-7.

Authors

S Pérez¹, R M Pérez, C Pérez, M A Zavala, R Vargas

Affiliation

¹ Universidad Autónoma Metropolitana, Xochimilco, Mexico, Mexico.

PMID: 7846084
DOI: 10.1016/0031-6865(94)90016-7

Abstract

A new compound, 3-methylenhydroxy-5-methoxy-2,4-dihydroxy tetrahydrofurane, has been isolated from a methanol extract of Selaginella lepidophyla. The structure is based on 1H-NMR, 13C-NMR and MS analysis. The compound was tested on uterus (oestrus), ileum and duodenum of Wistar rats. It proved to have a slight inhibitory effect on the contraction response of the uterus, but it did not have any effect on the two other muscles.

MeSH terms

Animals
Female
Furans / isolation & purification
Furans / pharmacology*
In Vitro Techniques
Mexico
Muscle, Smooth / drug effects*
Plants, Medicinal / chemistry*
Rats
Rats, Wistar
Southwestern United States
Uterine Contraction / drug effects

Substances

3-methylenehydroxy-5-methoxy-2,4-dihydroxytetrahydrofuran
Furans