Abstract
The term "granulomatous slack skin" (GSS) was introduced by Ackerman for a disease first described by Convit et al. in 1973. GSS represents a rare cutaneous lymphoma characterized by localized elastolytic lesions with a granulomatous infiltrate. We recently observed two male patients with the characteristic features of this disease. Both patients responded well to therapy with interferon-alpha 2b. In one patient clinical remission was stable under long-term treatment with clofazimine. We report on common features of these two patients and give a review of the cases published in the literature.
MeSH terms
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Biopsy
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Clofazimine / therapeutic use
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Combined Modality Therapy
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Ehlers-Danlos Syndrome / diagnosis*
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Ehlers-Danlos Syndrome / pathology
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Ehlers-Danlos Syndrome / therapy
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Elastic Tissue / pathology
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Etretinate / therapeutic use
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Hodgkin Disease / diagnosis*
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Hodgkin Disease / pathology
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Hodgkin Disease / therapy
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Humans
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Interferon alpha-2
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Interferon-alpha / therapeutic use
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Lymphoma, T-Cell, Cutaneous / diagnosis*
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Lymphoma, T-Cell, Cutaneous / pathology
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Lymphoma, T-Cell, Cutaneous / therapy
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Male
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Middle Aged
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Recombinant Proteins
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Skin / pathology
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Skin Neoplasms / diagnosis*
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Skin Neoplasms / pathology
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Skin Neoplasms / therapy
Substances
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Interferon alpha-2
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Interferon-alpha
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Recombinant Proteins
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Etretinate
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Clofazimine