["Granulomatous slack skin"--cutaneous elastolytic lymphoma]

Hautarzt. 1994 Dec;45(12):861-5. doi: 10.1007/s001050050187.
[Article in German]

Abstract

The term "granulomatous slack skin" (GSS) was introduced by Ackerman for a disease first described by Convit et al. in 1973. GSS represents a rare cutaneous lymphoma characterized by localized elastolytic lesions with a granulomatous infiltrate. We recently observed two male patients with the characteristic features of this disease. Both patients responded well to therapy with interferon-alpha 2b. In one patient clinical remission was stable under long-term treatment with clofazimine. We report on common features of these two patients and give a review of the cases published in the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biopsy
  • Clofazimine / therapeutic use
  • Combined Modality Therapy
  • Ehlers-Danlos Syndrome / diagnosis*
  • Ehlers-Danlos Syndrome / pathology
  • Ehlers-Danlos Syndrome / therapy
  • Elastic Tissue / pathology
  • Etretinate / therapeutic use
  • Hodgkin Disease / diagnosis*
  • Hodgkin Disease / pathology
  • Hodgkin Disease / therapy
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use
  • Lymphoma, T-Cell, Cutaneous / diagnosis*
  • Lymphoma, T-Cell, Cutaneous / pathology
  • Lymphoma, T-Cell, Cutaneous / therapy
  • Male
  • Middle Aged
  • Recombinant Proteins
  • Skin / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy

Substances

  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Etretinate
  • Clofazimine