Abstract
Halicylindramides A-C (1-3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification*
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Lactones
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Leukemia P388
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Sequence Data
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Peptides, Cyclic / pharmacology*
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Porifera / chemistry*
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Spectrum Analysis
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Tumor Cells, Cultured
Substances
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Antifungal Agents
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Antineoplastic Agents
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Cytotoxins
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Lactones
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Peptides, Cyclic