Aspartyl alpha-((diphenylphosphinyl)oxy)methyl ketones as novel inhibitors of interleukin-1 beta converting enzyme. Utility of the diphenylphosphinic acid leaving group for the inhibition of cysteine proteases

J Med Chem. 1995 Jan 20;38(2):220-2. doi: 10.1021/jm00002a002.
No abstract available

MeSH terms

  • Aspartic Acid / chemistry
  • Aspartic Acid / pharmacology*
  • Calpain / antagonists & inhibitors
  • Caspase 1
  • Cathepsin B / antagonists & inhibitors
  • Cysteine Endopeptidases / metabolism*
  • Cysteine Proteinase Inhibitors*
  • Ketones / chemistry
  • Ketones / pharmacology*
  • Structure-Activity Relationship

Substances

  • Cysteine Proteinase Inhibitors
  • Ketones
  • Aspartic Acid
  • Calpain
  • Cysteine Endopeptidases
  • Cathepsin B
  • Caspase 1