There is evidence that, in addition to Kaposi's sarcoma, high-grade non-Hodgkin's lymphoma, and invasive cervical carcinoma (the only malignancies diagnostic per se of AIDS), other tumors have been occurring in the HIV setting, often with peculiar clinicopathologic characteristics. Because the survival of patients with HIV infection has improved owing to the better prevention and management of opportunistic infections, it is highly likely that these malignancies will increase in the next few years. The study of these tumors will help us better understand the relationship between the prolonged immunosuppression and the development of tumors.