Minimal inhibitory concentrations (MICs) of amoxycillin alone and in combination with 2 mg/l or 4 mg/l clavulanic acid, ampicillin alone and in combination with 4 mg/l or 8 mg/l sulbactam, cefuroxime and cefaclor, were determined by the agar dilution method, with bacterial inoculum size ranging from 3 x 10(7) to 3 x 10(9) colony-forming units per ml. As expected, an inoculum effect was observed with cefaclor. In contrast, MICs of amoxycillin in combination with clavulanic acid did not significantly increase with the inoculum size. Ampicillin combined with sulbactam, and cefuroxime were less efficient at the highest bacterial concentration tested.