The aim of the study was to choose a suitable base for the topical application of pentacaine chloride and heptacaine chloride. Both local anaesthetics were processed into two hydrophilic creams, two hydrophobic creams and one hydrophobic ointment as well as into three hydrogel bases. The assumption that the rate of the release of both local anaesthetics from hydrogel bases is greater than from cream bases has been fully confirmed.