Antioxidant activity of nitecapone and its analog OR-1246: effect of structural modification on antioxidant action

Methods Enzymol. 1994:234:526-41. doi: 10.1016/0076-6879(94)34125-7.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Catechols / chemistry
  • Catechols / pharmacology*
  • Cytochrome c Group / drug effects
  • Cytochrome c Group / metabolism*
  • Dose-Response Relationship, Drug
  • Free Radical Scavengers / pharmacology*
  • Free Radicals
  • Indicators and Reagents
  • Kinetics
  • Liposomes
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • Oxidation-Reduction
  • Pentanones / chemistry
  • Pentanones / pharmacology*
  • Peroxides
  • Phosphatidylcholines
  • Rats
  • Solutions
  • Spectrometry, Fluorescence / methods
  • Spectrophotometry / methods
  • Structure-Activity Relationship
  • Superoxides
  • Thiobarbituric Acid Reactive Substances / analysis

Substances

  • Antioxidants
  • Catechols
  • Cytochrome c Group
  • Free Radical Scavengers
  • Free Radicals
  • Indicators and Reagents
  • Liposomes
  • Pentanones
  • Peroxides
  • Phosphatidylcholines
  • Solutions
  • Thiobarbituric Acid Reactive Substances
  • Superoxides
  • OR 1246
  • perhydroxyl radical
  • nitecapone
  • 1,2-oleoylphosphatidylcholine