Owing to its numerous biological characteristics, Tissucol fibrin cement is widely used in general and specialised surgery. In urology it is used on both the renal parenchyma and on the entire urinary tract. The authors report their experience regarding the use of Tissucol in the execution of urethro-vescical anastomosis during radical prostatectomy and cystectomy with orthotopic neovescica according to Camey II. A group of 25 patients were examined of whom 10 with vescical neoplasia and 25 with cancer of the prostate. Anastomosis was always performed using four or five suture stitches in Dexon 2/0 and subsequently sealed with Tissucol. Suture condition was regularly checked using contrastography. The suture only gave way in one case of orthotopic neovescica with consequent urinary fistula; in all the other cases the anastomosis showed a perfect seal in both the short and long term. In the authors' opinion the good immediate result of anastomosis can significantly reduce the postoperative hospitalization.