Anticancer effects of adriamycin-loaded hydroxyapatite implants determined in a Swarm rat chondrosarcoma model

Jpn J Pharmacol. 1994 Jul;65(3):289-91. doi: 10.1254/jjp.65.289.

Abstract

We investigated the antitumor effects of adriamycin (ADR)-loaded hydroxyapatite (HAP) beads in a Swarm rat chondrosarcoma model. When one ADR-loaded HAP bead (ADR: 0.8 mg/bead) was implanted into the central portion of a rat bearing tumor, the ADR-loaded HAP beads showed good therapeutic effects, increasing the life span (ILS) by 90%. Significantly, leukopenia and diarrhea were not observed. These results suggest that HAP delivery offers an interesting and a potentially effective method.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bone Neoplasms / drug therapy*
  • Chondrosarcoma / drug therapy*
  • Delayed-Action Preparations
  • Disease Models, Animal
  • Doxorubicin / administration & dosage
  • Doxorubicin / therapeutic use*
  • Drug Delivery Systems
  • Durapatite / chemistry
  • Durapatite / metabolism
  • Female
  • Life Expectancy
  • Male
  • Prostheses and Implants
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Delayed-Action Preparations
  • Doxorubicin
  • Durapatite