Developmental changes of alpha 1-adrenergic chronotropic action on human sinus node

H Saitoh; A Nomura; M Osaka; N Sasabe; H Atarashi; H Hayakawa

doi:10.1016/s0002-9149(99)80811-x

Developmental changes of alpha 1-adrenergic chronotropic action on human sinus node

Am J Cardiol. 1995 Jul 1;76(1):89-91. doi: 10.1016/s0002-9149(99)80811-x.

Authors

H Saitoh¹, A Nomura, M Osaka, N Sasabe, H Atarashi, H Hayakawa

Affiliation

¹ First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.

PMID: 7793415
DOI: 10.1016/s0002-9149(99)80811-x

Abstract

The important role of alpha 1-adrenoceptors in reperfusion ventricular arrhythmia is mentioned in the introduction. However, the present report is concerned with the sinus node. It is speculated that the decreased positive chronotropic action of alpha 1-adrenergic stimulation due to aging may contribute to the development of sick sinus syndrome.

MeSH terms

Adolescent
Adult
Age Factors
Aged
Blood Pressure / drug effects
Female
Heart Conduction System / drug effects
Heart Conduction System / physiopathology*
Heart Rate / drug effects*
Humans
Male
Middle Aged
Muscle, Smooth, Vascular / physiology
Phenylephrine / pharmacology*
Receptors, Adrenergic, alpha-1 / physiology*
Sinoatrial Node / drug effects
Sinoatrial Node / physiopathology

Substances

Receptors, Adrenergic, alpha-1
Phenylephrine