RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities

M Ubukata; N Shiraishi; K Kobinata; T Kudo; I Yamaguchi; H Osada; Y C Shen; K Isono

doi:10.7164/antibiotics.48.289

RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 1995 Apr;48(4):289-92. doi: 10.7164/antibiotics.48.289.

Authors

M Ubukata¹, N Shiraishi, K Kobinata, T Kudo, I Yamaguchi, H Osada, Y C Shen, K Isono

Affiliation

¹ Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.

PMID: 7775264
DOI: 10.7164/antibiotics.48.289

Abstract

Three novel 36-membered macrolide antibiotics, RS-22A, B and C produced by Streptomyces violaceusniger have been isolated. These antibiotics were purified from an acetone extract of the mycelia followed by butanol extraction, centrifugal partition chromatography and HPLC. RS-22A, B, C showed antimicrobial activity against fungi and Gram-positive bacteria.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Centrifugation
Chromatography
Chromatography, High Pressure Liquid
Fermentation
Fungi / drug effects
Gram-Positive Bacteria / drug effects
Macrolides*
Molecular Structure
Streptomyces / classification
Streptomyces / growth & development
Streptomyces / metabolism*

Substances

Anti-Bacterial Agents
Antifungal Agents
Macrolides
RS 22A
RS 22B
RS 22C