Lanosterol and 27-norlanosterol oligosaccharides from the bulbs of Chionodoxa gigantea

Y Mimaki; S Kubo; Y Kinoshita; Y Sashida; L G Song; T Nikaido; T Ohmoto

doi:10.1016/0031-9422(93)85361-t

Lanosterol and 27-norlanosterol oligosaccharides from the bulbs of Chionodoxa gigantea

Phytochemistry. 1993 Oct;34(3):791-7. doi: 10.1016/0031-9422(93)85361-t.

Authors

Y Mimaki¹, S Kubo, Y Kinoshita, Y Sashida, L G Song, T Nikaido, T Ohmoto

Affiliation

¹ Tokyo College of Pharmacy, Japan.

PMID: 7764152
DOI: 10.1016/0031-9422(93)85361-t

Abstract

New lanosterol and 27-norlanosterol oligosaccharides were found in the bulbs of Chionodoxa gigantea. Their structures were established mainly by extensive 2D NMR analysis as well as by comparison with spectral data of known compounds. The inhibition of cyclic AMP phosphodiesterase by the lanosterol derivatives was assayed as the primary screening test to find new medicinal materials.

MeSH terms

3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors
Carbohydrate Sequence
Lanosterol / analogs & derivatives*
Lanosterol / chemistry
Lanosterol / isolation & purification*
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Oligosaccharides / chemistry
Oligosaccharides / isolation & purification*
Oligosaccharides / pharmacology
Plants / chemistry*

Substances

Oligosaccharides
Lanosterol
3',5'-Cyclic-AMP Phosphodiesterases