A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample

J Med Genet. 1995 Feb;32(2):131-4. doi: 10.1136/jmg.32.2.131.

Abstract

Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Bipolar Disorder / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Linkage / genetics
  • Genetic Markers / genetics
  • Genetics, Population
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Polymorphism, Genetic
  • Receptors, Dopamine D2 / genetics*
  • Repetitive Sequences, Nucleic Acid / genetics
  • Spain
  • Tyrosine 3-Monooxygenase / genetics*

Substances

  • Genetic Markers
  • Receptors, Dopamine D2
  • Tyrosine 3-Monooxygenase