The surgery Department of the Regional Hospital was opened on 1st July, 1894 in Sarajevo, what meant the beginnings of European surgery school influence here. The School was in the second half of its activity, better known as "century of surgery". The building, fittings, equipment and staff continued their work here coping the Viennese school achievements. It was headed by the prominent European surgeon, primarius Dr Josef Preindisberger, first assistant to the great personality Dr. Billroth. In the way this institution became a referral centre for two other hospitals in Sarajevo: the Vakuf's and the Military Hospital, but for some 17 more in BH, which were built in the course of ten years. Because of the therapeutic success in the domain of the general surgery and diseases of the eye and according the annual reports, the first 50 beds became insufficient for all those who wanted the treatment. So, the Department was enlarged, in 1905 a new regional Hospital was planned, to act as clinics. The World War 1 stopped the plans. During the period of Kingdom of Yugoslavia, destroyed by war, the Surgery Department continued its work with the doctors educated to continue the work on the pre war level. As a broad pathology basis, but the need of space that time chief surgeon. Primarius Milivoje Kostić worked out in details the former plan of the new hospital building up with a base for clinics. It was accepted as a ten years project, which, to the regrets, did not come to existence to the World War 2.(ABSTRACT TRUNCATED AT 250 WORDS)