Influence of teniposide on platelet functions in vitro

P Kubisz; F Seghier; M Dobrotorá; J Stasko; S Cronberg

doi:10.1016/0049-3848(95)91620-z

Influence of teniposide on platelet functions in vitro

Thromb Res. 1995 Jan 15;77(2):145-8. doi: 10.1016/0049-3848(95)91620-z.

Authors

P Kubisz¹, F Seghier, M Dobrotorá, J Stasko, S Cronberg

Affiliation

¹ Division of Hematology, University Hospital, Martin, Slovakia.

PMID: 7740506
DOI: 10.1016/0049-3848(95)91620-z

Abstract

Teniposide added to citrated platelet-rich plasma reduced platelet aggregation induced by collagen, but did not interfere with ADP-induced aggregation. The availability of platelet factor 3 was decreased irrespective of inducer. Reptilase clot retraction induced by ADP or collagen was reduced. Teniposide did not interfere with platelet adhesion to glass. It did not release lactic dehydrogenase from the cytoplasm of platelets. Coagulation factors were not affected.

MeSH terms

Adenosine Diphosphate / pharmacology
Blood Coagulation Tests
Blood Platelets / drug effects*
Cells, Cultured
Clot Retraction
Collagen / antagonists & inhibitors
Glass
Humans
L-Lactate Dehydrogenase / metabolism
Platelet Adhesiveness / drug effects
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / pharmacology
Platelet Factor 3 / analysis
Teniposide / pharmacology*
Thrombin Time

Substances

Platelet Aggregation Inhibitors
Platelet Factor 3
Adenosine Diphosphate
Collagen
Teniposide
L-Lactate Dehydrogenase