A new case of subcutaneous Human Dirofilariasis, in a 42-year-old woman from the province of Cosenza, is described. It is the first reported in Calabria. The nematode, an immature female of Dirofilaria repens, was clinically diagnosed as a "Fibrolipoma". In a collateral research on dogs in different areas of the same province, microfilariae of D. repens in 2 out 134 individuals were detected.