Individualized gonadotropin regimens for follicular stimulation in macaques during in vitro fertilization (IVF) cycles

J Med Primatol. 1994 Sep;23(7):367-74. doi: 10.1111/j.1600-0684.1994.tb00122.x.

Abstract

Follicular stimulation was compared in macaques receiving sequential gonadotropin treatment which was terminated after seven, eight, or nine days depending on the time required to attain preselected criteria of follicular maturation. Although estradiol levels and follicle sizes varied, the number of follicles and oocytes/animal, oocyte nuclear maturity, IVF rates and progesterone levels during the luteal phase were similar among groups. Reducing the duration of gonadotropin treatment to individualize follicular stimulation regimens does not compromise follicle or gamete quality.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Estradiol / blood
  • Female
  • Fertilization in Vitro / veterinary*
  • Follicle Stimulating Hormone / pharmacology*
  • Humans
  • Insemination
  • Luteinizing Hormone / pharmacology*
  • Macaca mulatta*
  • Male
  • Menstrual Cycle
  • Oocytes / drug effects
  • Ovarian Follicle / anatomy & histology
  • Ovarian Follicle / drug effects*
  • Ovarian Follicle / physiology
  • Radioimmunoassay
  • Time Factors

Substances

  • Estradiol
  • Luteinizing Hormone
  • Follicle Stimulating Hormone