Structure activity studies on chemically modified homologues of the antibiotic phytotoxic leucinostatin A

G Vertuani; M Boggian; A Scatturin; M Ricci; B Meli Balbocchino; L Tuttobello; C Rossi

doi:10.7164/antibiotics.48.254

Structure activity studies on chemically modified homologues of the antibiotic phytotoxic leucinostatin A

J Antibiot (Tokyo). 1995 Mar;48(3):254-60. doi: 10.7164/antibiotics.48.254.

Authors

G Vertuani¹, M Boggian, A Scatturin, M Ricci, B Meli Balbocchino, L Tuttobello, C Rossi

Affiliation

¹ Dipartimento de Scienze Farmaceutiche, Università di Ferrara, Italy.

PMID: 7730161
DOI: 10.7164/antibiotics.48.254

Abstract

The synthesis and a conformational study of a number of homologues of the well known antibiotic, phytotoxic leucinostatin A are reported. The circular dichroism of all the compounds are discussed. Some conclusions on the SAR of these compounds are drawn. The influence of the alpha-helical conformation and/or the increased lipophile character on their interesting biological activities is emphasized.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Antibiotics, Antineoplastic / chemical synthesis
Antibiotics, Antineoplastic / chemistry*
Antibiotics, Antineoplastic / pharmacology
Antimicrobial Cationic Peptides
Circular Dichroism
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Molecular Sequence Data
Peptides*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Antibiotics, Antineoplastic
Antimicrobial Cationic Peptides
Peptides
leucinostatin A