Abstract
Synthesis and pharmacological evaluation of novel indazole derivatives are described. These compounds were found to exhibit both thromboxane A2 (TXA2) synthetase-inhibitory and bronchodilatory activities. This observation supports the idea that the partial structure of the 3-pyridyl and phenyl groups with a methylene insertion is an important component for well-balanced activities.
MeSH terms
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Administration, Oral
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Aminophylline / pharmacology
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Animals
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Benzofurans / pharmacology
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Bronchodilator Agents / chemical synthesis*
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Bronchodilator Agents / chemistry
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Bronchodilator Agents / pharmacology
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Fatty Acids, Monounsaturated / pharmacology
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Guinea Pigs
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Histamine Antagonists / chemical synthesis
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Histamine Antagonists / pharmacology
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In Vitro Techniques
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Indazoles / chemistry*
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Indazoles / pharmacology
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Male
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Methacrylates / pharmacology
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Pentanoic Acids / pharmacology
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Pyridines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
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Thromboxane-A Synthase / antagonists & inhibitors*
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Thromboxane-A Synthase / blood
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Trachea / drug effects
Substances
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Benzofurans
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Bronchodilator Agents
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Fatty Acids, Monounsaturated
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Histamine Antagonists
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Indazoles
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Methacrylates
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Pentanoic Acids
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Pyridines
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Aminophylline
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Thromboxane-A Synthase
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isbogrel
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furegrelate
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ozagrel
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ridogrel