Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones as potential platelet aggregation inhibitors

B Tozkoparan; H Akgün; M Ertan; K Rübsemann

doi:10.1002/ardp.19953280215

Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones as potential platelet aggregation inhibitors

Arch Pharm (Weinheim). 1995 Feb;328(2):169-73. doi: 10.1002/ardp.19953280215.

Authors

B Tozkoparan¹, H Akgün, M Ertan, K Rübsemann

Affiliation

¹ Hacettepe University, Faculty of Pharmacy, Dept. of Pharmaceutical Chemistry, Ankara, Turkey.

PMID: 7726744
DOI: 10.1002/ardp.19953280215

Abstract

Twenty new compounds having 2-methyl-6-benzylidenethiazolo[3,2-b]- 1,2,4-triazole-5(6H)-one (2a-d) and 2-methyl-6-(alpha-aminobenzyl)thiazolo-[3,2-b]-1,2,4- triazole-5-ol (5-20) structures were synthesized. Their structures were confirmed by elemental and spectroscopic analysis and their platelet aggregation inhibitory activities were investigated.

MeSH terms

Humans
In Vitro Techniques
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / chemical synthesis*
Platelet Aggregation Inhibitors / pharmacology
Thiazoles / chemical synthesis*
Thiazoles / pharmacology
Triazoles / chemical synthesis*
Triazoles / pharmacology

Substances

Platelet Aggregation Inhibitors
Thiazoles
Triazoles