Abstract
The successful experimental transmission of enzootic intranasal tumor (EIT) from goat to goat is described. Ten kids, less than 48 hours old, from a flock free of the disease and seronegative for ruminant lentiviruses were inoculated intranasally or intrasinusally with either nasal fluid from goats with naturally occurring EIT or EIT retrovirus concentrated from such fluids. EIT was induced in three kids after 12-24 months. The EIT retrovirus was demonstrated in tumor material from each of the three kids by western blotting and electron microscopy. All kids were seronegative for ruminant lentiviruses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / pathology
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Adenocarcinoma / veterinary*
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Adenocarcinoma / virology
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Animals
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Blotting, Western / veterinary
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Disease Transmission, Infectious
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Goat Diseases / pathology
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Goat Diseases / transmission*
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Goats
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Microscopy, Electron / veterinary
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Morbidity
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Nasal Cavity / pathology
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Nasal Cavity / ultrastructure
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Nasal Cavity / virology
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Nose Neoplasms / pathology
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Nose Neoplasms / veterinary*
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Nose Neoplasms / virology
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Retroviridae / isolation & purification
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Retroviridae Infections / pathology
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Retroviridae Infections / transmission
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Retroviridae Infections / veterinary*
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Time Factors