The endozepine ODN stimulates polyphosphoinositide metabolism in rat astrocytes

FEBS Lett. 1995 Apr 3;362(2):106-10. doi: 10.1016/0014-5793(95)00209-r.

Abstract

Astrocytes synthesize a series of peptides called endozepines which act as endogenous ligands of benzodiazepine receptors. The present study demonstrates that the endozepine ODN causes a dose-dependent increase in inositol trisphosphate and a parallel decrease in phosphatidylinositol bisphosphate in cultured rat astrocytes. Pre-incubation of astrocytes with the phospholipase C inhibitor U 73122 or with pertussis toxin totally blocked polyphosphoinositide metabolism. These data show that, in rat astrocytes, ODN stimulates a phospholipase C coupled to a pertussis toxin-sensitive G protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / drug effects
  • Astrocytes / metabolism*
  • Diazepam Binding Inhibitor
  • Inositol / metabolism
  • Kinetics
  • Neuropeptides / pharmacology*
  • Peptide Fragments
  • Pertussis Toxin
  • Phosphatidylinositols / metabolism*
  • Phospholipids / metabolism
  • Rats
  • Rats, Wistar
  • Tritium / metabolism
  • Type C Phospholipases / metabolism
  • Virulence Factors, Bordetella / pharmacology

Substances

  • Diazepam Binding Inhibitor
  • Neuropeptides
  • Peptide Fragments
  • Phosphatidylinositols
  • Phospholipids
  • Virulence Factors, Bordetella
  • diazepam binding inhibitor (33-50)
  • Tritium
  • Inositol
  • Pertussis Toxin
  • Type C Phospholipases