Aurantimycins, new depsipeptide antibiotics from Streptomyces aurantiacus IMET 43917. Production, isolation, structure elucidation, and biological activity

J Antibiot (Tokyo). 1995 Feb;48(2):119-25. doi: 10.7164/antibiotics.48.119.

Abstract

Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field homo- and heteronuclear 2D NMR experiments, high-resolution mass spectrometry and amino acid analysis. Aurantimycins are characterized by a new side chain containing fourteen carbon atoms. They display strong activity against Gram-positive bacteria and cytotoxic effects against L-929 mouse fibroblast cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Cell Line
  • Cytotoxins / biosynthesis
  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification
  • Cytotoxins / pharmacology
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Peptides*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Streptomyces / metabolism*
  • X-Ray Diffraction

Substances

  • Anti-Bacterial Agents
  • Cytotoxins
  • Peptides