N-(indol-3-ylglyoxylyl)amino acid ester derivatives. Synthesis and interaction properties at the benzodiazepine receptor

Farmaco. 1995 Jan;50(1):5-12.

Abstract

Several N-(indol-3-ylglyoxylyl)alanine and glycine ester derivatives were prepared to evaluate the influence of the ester group size both on affinity and on activity at the benzodiazepine receptor. Moreover, indol-3-ylglyoxylic acid esters, closely related to 3-alkoxy-beta-carbolines, were synthesized and tested in vitro on the benzodiazepine receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Flunitrazepam / metabolism
  • Indoles / chemical synthesis*
  • Indoles / metabolism
  • Receptors, GABA-A / metabolism*
  • Structure-Activity Relationship

Substances

  • Indoles
  • Receptors, GABA-A
  • Flunitrazepam