Abstract
Mortalin has been shown to exhibit differential distributions in cells with mortal and immortal phenotypes. In the present study, we report mot-2 cDNA cloning from RS-4 cells--an immortal clone from CD1-ICR mouse embryonic fibroblasts--and the chromosomal assignments of mortalin related genes to mouse chromosomes 18 and X by fluorescence in situ hybridization. Similar analysis assigned the gene to chromosome 5q31.1 in human.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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CHO Cells
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Carrier Proteins
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Cell Line
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Chromosome Mapping*
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Chromosomes, Human, Pair 5*
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Cricetinae
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Embryo, Mammalian
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Fibroblasts
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HSP70 Heat-Shock Proteins / genetics*
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Heat-Shock Proteins / genetics*
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Hominidae / genetics*
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Humans
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In Situ Hybridization, Fluorescence
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Karyotyping
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Lymphocytes / metabolism
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Mice
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Mice, Inbred ICR / genetics
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Mice, Inbred Strains / genetics*
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Mitochondrial Proteins
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Multigene Family*
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X Chromosome
Substances
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Carrier Proteins
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HSP70 Heat-Shock Proteins
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HSPA9 protein, human
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Heat-Shock Proteins
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Hspa9 protein, mouse
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Mitochondrial Proteins
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mortalin