Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteins

FEBS Lett. 1995 Mar 20;361(2-3):269-72. doi: 10.1016/0014-5793(95)00177-b.

Abstract

Mortalin has been shown to exhibit differential distributions in cells with mortal and immortal phenotypes. In the present study, we report mot-2 cDNA cloning from RS-4 cells--an immortal clone from CD1-ICR mouse embryonic fibroblasts--and the chromosomal assignments of mortalin related genes to mouse chromosomes 18 and X by fluorescence in situ hybridization. Similar analysis assigned the gene to chromosome 5q31.1 in human.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CHO Cells
  • Carrier Proteins
  • Cell Line
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 5*
  • Cricetinae
  • Embryo, Mammalian
  • Fibroblasts
  • HSP70 Heat-Shock Proteins / genetics*
  • Heat-Shock Proteins / genetics*
  • Hominidae / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Lymphocytes / metabolism
  • Mice
  • Mice, Inbred ICR / genetics
  • Mice, Inbred Strains / genetics*
  • Mitochondrial Proteins
  • Multigene Family*
  • X Chromosome

Substances

  • Carrier Proteins
  • HSP70 Heat-Shock Proteins
  • HSPA9 protein, human
  • Heat-Shock Proteins
  • Hspa9 protein, mouse
  • Mitochondrial Proteins
  • mortalin