Antigenic sites on type 2 poliovirus

Abstract

Monoclonal escape variants isolated from the Sabin strain of type 2 poliovirus were examined. Mutations were identified in regions known to be antigenic in other serotypes, although the extent to which they were linked by common antibodies varied. One complex site involved regions of VP2 and VP3 which were not linked in early studies, but have recently been shown by others to be linked in type 1.