The structure-activity relationship of a new anti-arrhythmic agent 1-[2-acetoxy-3-(4-phenyl-1-piperazinyl)propyl]pyrrolidin-2-one

Arch Pharm (Weinheim). 1995 Jun;328(6):541-6. doi: 10.1002/ardp.19953280613.

Abstract

This paper reports the synthesis of the new compound 1-[2-acetoxy-3-(4-phenyl-1-piperazinyl)propyl]pyrrolidin-2-one (Ac-MG-1). Preliminary pharmacological assessment revealed that Ac-MG-1 possesses anti-arrhythmic activity and a local anesthetic effect. The crystal structure of Ac-MG-1 was determined by X-ray diffraction, and conformational analysis was performed both for Ac-MG-1 and for other derivatives of (arylpiperazinyl)propylpyrrolidin-2-one.

MeSH terms

  • Anesthetics, Local / pharmacology
  • Animals
  • Anti-Arrhythmia Agents / chemical synthesis*
  • Anti-Arrhythmia Agents / pharmacology
  • Cricetinae
  • Lethal Dose 50
  • Male
  • Mice
  • Molecular Conformation
  • Pyrrolidinones / chemical synthesis*
  • Pyrrolidinones / pharmacology
  • Rats
  • Rats, Wistar
  • Structure-Activity Relationship

Substances

  • 1-(2-acetoxy-3-(4-phenyl-1-piperazinyl)propyl)pyrrolidin-2-one
  • Anesthetics, Local
  • Anti-Arrhythmia Agents
  • Pyrrolidinones